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Dual targeting of PD-1/PD-L1 and iL-33/ST2 signalling pathways: a promising approach in breast cancer immunotherapy

Introduction The immune checkpoint axis PD-1/PD-L1 is a cornerstone of cancer immunotherapy. However, its efficacy in breast cancer is often limited by a complex and immunosuppressive tumour microenvironment (TME). The IL-33/ST2 signalling pathway, a key player in type 2 inflammation, is increasingl...

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Principais autores: Milan Jovanovic, Nevena Gajovic, Miodrag Jocic, Marina Jovanovic, Milena Jurisevic, Ivan Jovanovic
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Annals of Medicine
Fag:
Breast cancer
PD-1/PD-L1 pathway
IL-33/ST2 pathway
immunotherapy
combination therapy
Online adgang:https://www.tandfonline.com/doi/10.1080/07853890.2025.2593198
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