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Kidney allograft rejection is associated with an imbalance of B cells, regulatory T cells and differentiated CD28-CD8+ T cells: analysis of a cohort of 1095 graft biopsies

IntroductionThe human immune system contains cells with either effector/memory or regulatory functions. Besides the well-established CD4+CD25hiCD127lo regulatory T cells (Tregs), we and others have shown that B cells can also have regulatory functions since their frequency and number are increased i...

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Main Authors: Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anaïs Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
rejection
B lymphocytes
Treg
CD28-CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151127/full
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