Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects against dengue virus infection in mice

Objective: To evaluate the expression of DNA plasmid-harboring modified antibody gene that produces neutralizing human monoclonal antibodies against four serotypes of dengue virus (DENV) without enhancing activity in BALB/c mice. Methods: We constructed pFUSE-based vectors (pFUSE_1G7C2_ hVH and pFUS...

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Autores principales:	Surachet Benjathummarak, Atsushi Yamanaka, Thanyaluk Krasae, Chonlatip Pipattanaboon, Subenya Injampa, Pannamthip Pitaksajjakul, Pongrama Ramasoota
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wolters Kluwer Medknow Publications 2021-01-01
Colección:	Asian Pacific Journal of Tropical Medicine
Materias:	dengue virus; lala mutation; antibody-dependent enhancement (ade); antibody plasmid; electroporation
Acceso en línea:	http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=7;spage=299;epage=308;aulast=Benjathummarak
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