Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA

The virulence of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), depends on the expression of toxins and virulence factors controlled by the quorum-sensing (QS) system, encoded on the virulence accessory gene regulator (agr) locus. The aim of this study was to identify a phy...

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Manylion Llyfryddiaeth

Prif Awduron:	Junpei Yamaguchi, Teruhisa Manome, Yasumasa Hara, Yuriko Yamazaki, Yuumi Nakamura, Masami Ishibashi, Akiko Takaya
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2024-04-01
Cyfres:	Frontiers in Pharmacology
Pynciau:	physalins MRSA Agr-QS modulator anti-hemolytic activity AgrA-DNA inhibition molecular docking
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1365815/full
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