Repurposing AZD-5991 for inhibiting growth and biofilm formation of Staphylococcus aureus by disrupting the cell membrane and targeting FabI

Abstract Staphylococcus aureus infections have emerged as a global public health threat. Two key factors—drug resistance and biofilm formation—substantially impair the efficacy of the antimicrobial treatment for S. aureus infections using conventional antibiotics. Consequently, discovering novel ant...

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Principais autores:	Yuanyuan Tang, Han Deng, Zhichao Xu, Zhijian Yu, Yong Xiang, Zewen Wen, Shiqing Han, Zhong Chen, Tieying Hou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-07-01
coleção:	BMC Microbiology
Assuntos:	Staphylococcus aureus Antimicrobial activity AZD-5991 Biofilm FabI
Acesso em linha:	https://doi.org/10.1186/s12866-025-04104-2
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