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Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay

Antimalarial resistance to the first-line partner drug piperaquine (PPQ) threatens the effectiveness of artemisinin-based combination therapy. In vitro piperaquine resistance is characterized by incomplete growth inhibition, i.e. increased parasite growth at higher drug concentrations. However, the...

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Principais autores: Annabelle Walz, Sibylle Sax, Christian Scheurer, Balint Tamasi, Pascal Mäser, Sergio Wittlin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
PRR assay
drug resistance
piperaquine
parasite viability
growth inhibition assay
4-aminoquinoline
Online adgang:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1396786/full
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