Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway

Inhibitors of apoptosis proteins (IAPs) are validated onco-targets, as their overexpression correlates with cancer onset, progression, diffusion and chemoresistance. IAPs regulate cell death survival pathways, inflammation, and immunity. Targeting IAPs, by impairing their protein–protein interaction...

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Bibliografische gegevens

Hoofdauteurs:	Federica Cossu, Simone Camelliti, Daniele Lecis, Luca Sorrentino, Maria Teresa Majorini, Mario Milani, Eloise Mastrangelo
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Association for the Advancement of Science (AAAS) 2021-01-01
Reeks:	Computational and Structural Biotechnology Journal
Onderwerpen:	Virtual screening Inhibitor of apoptosis proteins Baculoviral IAP repeat IAP-antagonist NF-kB Drug discovery
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2001037021004992
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