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Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease

Abstract Background Current AT(N) stratification for Alzheimer’s disease (AD) accounts for complex combinations of amyloid (A), tau proteinopathy (T) and neurodegeneration (N) signatures. Understanding the transition between these different stages is a major challenge, especially in view of the rece...

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Main Authors: Sylvain Lehmann, Susanna Schraen-Maschke, Luc Buée, Jean-Sébastien Vidal, Constance Delaby, Christophe Hirtz, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stéphanie Bombois, Audrey Gabelle, Olivier Hanon, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Format: Artigo
Language:Inglês
Published: BMC 2024-10-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid
BACE1
Cerebrospinal fluid
Neurodegeneration
Neurogranin
Online Access:https://doi.org/10.1186/s13024-024-00755-3
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