Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice

Abstract Background Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-induced inflammation. However, which one of HDACs members in response to...

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Principais autores:	Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi, Jing-Guo Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-05-01
Series:	Arthritis Research & Therapy
Assuntos:	Gout HDAC3 Macrophage polarization HDAC3 inhibitor Monosodium urate crystals
Acceso en liña:	https://doi.org/10.1186/s13075-024-03335-4
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