Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis

Summary: Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs containing Kupffer cells (KuLOs) by recapitulating fe...

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Hlavní autoři:	Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-03-01
Edice:	Cell Reports
Témata:	CP: Stem cell research
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124724002468
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