Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor

Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage within a few weeks of treatment. Drug actions, besides reducing the availability of cholesterol, could contribute to cataract...

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Autors principals:	Richard J. Cenedella, Robert Jacob, Douglas Borchman, Daxin Tang, Amanda R. Neely, Abbas Samadi, R. Preston Mason, Patricia Sexton
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2004-07-01
Col·lecció:	Journal of Lipid Research
Matèries:	cholesterol lens membrane lipids anisotropy x-ray diffraction apoptosis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S002222752031779X
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