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Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based GLUT4 trafficking in human and mouse muscle...

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Principais autores: Jonas R Knudsen, Kaspar W Persson, Carlos Henriquez-Olguin, Zhencheng Li, Nicolas Di Leo, Sofie A Hesselager, Steffen H Raun, Janne R Hingst, Raphaël Trouillon, Martin Wohlwend, Jørgen FP Wojtaszewski, Martin AM Gijs, Thomas Elbenhardt Jensen
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-04-01
Serier:eLife
Fag:
skeletal muscle
GLUT4
insulin resistance
microtubules
kinesin
Online adgang:https://elifesciences.org/articles/83338
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