The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion

Abstract Background Type 3 von Willebrand disease (VWD) exhibits severe hemorrhagic tendency with complicated pathogenesis. The C-terminal cystine knot (CTCK) domain plays an important role in the dimerization and secretion of von Willebrand factor (VWF). The CTCK domain has four intrachain disulfid...

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Autores principales:	Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu, Yi Wu, Jingyu Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2021-11-01
Colección:	Thrombosis Journal
Materias:	von Willebrand factor (VWF) von Willebrand disease (VWD) cystine knot domain multimerization disulfide bond
Acceso en línea:	https://doi.org/10.1186/s12959-021-00348-w
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