Effect of acyclovir therapy on the outcome of mechanically ventilated patients with lower respiratory tract infection and detection of herpes simplex virus in bronchoalveolar lavage: protocol for a multicentre, randomised controlled trial (HerpMV)

Introduction Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients and is associated with a worse outcome. The aim of this study is to determine whether antiviral therapy in HSV-positive patients improves outcome.Methods and analysis Prospecti...

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Autors principals:	Stefan Kluge, Alexander Zarbock, Patrick Meybohm, Christian Putensen, Stefan Hagel, Mathias W Pletz, Michael Bauer, Christian Jung, Markus A Weigand, Thorsten Brenner, Markus Heim, Stefan Münster, Sven Bercker, Sandra Fiedler, Frank Bloos, Maria Deja, Christian Ertmer, Peter Rosenberger, Helene Häberle, Jochen Dutzmann, Charlotte Ling, Andreas Güldner, Johannes Ehler, Sebastian Weis, Nicole Brillinger, Sebastian Decker, Philipp Franken, Alexander Vogt, Tobias Lahmer, Silke Fortenbach, Stefan John, Marc M. Berger, Axel Nierhaus, Friedhelm Bach, Raphael Bruno, Michael Zoller, Sandra Frank, Sarah Müller, Markus Feußner, Heinrich V Groesdonk, Ulrich Frey, Jan-Martin Wischermann, Mareike Otto, Matthias Lindner, Jan Heyckendorf, Caterina Reuchsel, Bernd Reichmann
Format:	Artigo
Idioma:	Inglês
Publicat:	BMJ Publishing Group 2024-04-01
Col·lecció:	BMJ Open
Accés en línia:	https://bmjopen.bmj.com/content/14/4/e082512.full
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