Rational Engineering of a Brevinin-2 Peptide: Decoupling Potency from Toxicity Through C-Terminal Truncation and N-Terminal Chiral Substitution

<b>Background/Objectives</b>: The clinical potential of antimicrobial peptides (AMPs) against dual threats like antimicrobial resistance (AMR) and cancer is often limited by their high host cell toxicity. Here, we focused on brevinin-2OS (B2OS), a novel peptide from the skin of <i>Odorrana schmacker...

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Principais autores:	Aifang Yao, Zeyu Zhang, Zhengmin Song, Yi Yuan, Xiaoling Chen, Chengbang Ma, Tianbao Chen, Chris Shaw, Mei Zhou, Lei Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-08-01
coleção:	Antibiotics
Assuntos:	antimicrobial peptide brevinin-2 peptide modification structure–activity relationship therapeutic index
Acesso em linha:	https://www.mdpi.com/2079-6382/14/8/784
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