Plasmacytoid dendritic cells respond directly to apoptotic cells by secreting immune regulatory IL-10 or IFNα

Plasmacytoid dendritic cells (pDCs) play a pivotal role in driving the autoimmune disease systemic lupus erythematosus, via the secretion of IFNα in response to nuclear self-antigens complexed with auto-antibodies. Apoptotic cells, generated at sites of inflammation or secondary lymphoid organs, are...

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Главные авторы:	Joanne Simpson, Katherine Miles, Marta Trub, Roisin MacMahon, Mohini Gray
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2016-12-01
Серии:	Frontiers in Immunology
Предметы:	Apoptosis IL-10 plasmacytoid dendritic cells TLRs (Toll-like receptors) apoptotic cells
Online-ссылка:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00590/full
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