Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

Idiosyncratic drug-induced liver injury (iDILI) is a major concern in drug development because its occurrence is unpredictable. Presently, iDILI prediction is a challenge, and cell toxicity is observed only at concentrations that are much higher than the therapeutic doses in preclinical models. Appl...

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Ngā kaituhi matua:	Salomé Roux, Sara Cherradi, Hong Tuan Duong
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2024-04-01
Rangatū:	Frontiers in Pharmacology
Ngā marau:	educated spheroid model drug-induced liver injury idiosyncratic immune-mediated idiosyncratic drug-induced liver injury risk prediction
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1378371/full
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