Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity

Summary: It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and the physiological consequences of enhancing tumor suppressor activity. Dele...

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Autors principals:	Eva Tsaousidou, Jędrzej Chrzanowski, Pascal Drané, Grace Y. Lee, Nadine Bahour, Zeqiu Branden Wang, Shijun Deng, Zhe Cao, Kaimeng Huang, Yizhou He, Mateusz Kaminski, Dominika Michalek, Ekin Güney, Kalindi Parmar, Wojciech Fendler, Dipanjan Chowdhury, Gökhan S. Hotamışlıgil
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-06-01
Col·lecció:	Cell Reports
Matèries:	CP: Cancer CP: Metabolism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S221112472400665X
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