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Boc5, a non-peptidic glucagon-like Peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice.

<h4>Background</h4>Our recent discovery of the substituted cyclobutane Boc5, one of the first non-peptidic agonists at glucagon-like peptide-1 receptors, offers the potential of combining oral availability with full agonism capable of eliciting antidiabetic and antiobesity effects. The present study...

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Principais autores: Haoran Su, Min He, Hongmei Li, Qing Liu, Jia Wang, Yiqian Wang, Weiwei Gao, Ling Zhou, Jiayu Liao, Andrew A Young, Ming-Wei Wang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2008-08-01
Serier:PLoS ONE
Online adgang:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002892&type=printable
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