Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT

Obacunone, a limonin triterpenoid extracted from Phellodendronchinense Schneid or Dictamnus dasycarpusb Turcz plant, elicits a variety of pharmacological effects such as anti-inflammatory, anti-neoplastic, anti-oxidation, and anti-lung-fibrosis ones. However, the anti-fibrotic effect of obacunone an...

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Autors principals:	Yongquan Bai, Wenwen Wang, Li Wang, Lirong Ma, Dongsheng Zhai, Furong Wang, Rui Shi, Chaoyang Liu, Qing Xu, Guo Chen, Zifan Lu
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2021-01-01
Col·lecció:	Molecules
Matèries:	obacunone liver fibrosis EMT hepatic stellate cells GPx-4 TGF-β
Accés en línia:	https://www.mdpi.com/1420-3049/26/2/318
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