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Photo-activation of the hydrophobic probe iodonaphthylazide in cells alters membrane protein function leading to cell death

<p>Abstract</p> <p>Background</p> <p>Photo-activation of the hydrophobic membrane probe 1, 5 iodonaphthylazide (INA) by irradiation with UV light (310–380 nm) results in the covalent modification of transmembrane anchors of membrane proteins. This unique selectivity of INA towards the transmembrane...

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Principais autores: Blumenthal Robert, Garg Himanshu, Viard Mathias, Raviv Yossef
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2009-03-01
Series:BMC Cell Biology
Acceso en liña:http://www.biomedcentral.com/1471-2121/10/21
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