Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Abstract Background Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote. However, a design strategy for antidote sequences ag...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Toru Yoshitomi, Koji Wakui, Masato Miyakawa, Keitaro Yoshimoto
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-07-01
Edice:	Research and Practice in Thrombosis and Haemostasis
Témata:	anticoagulant antidote DNA aptamer thrombin
On-line přístup:	https://doi.org/10.1002/rth2.12503
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!