Evening administration of long-acting muscarinic antagonists in COPD – a randomized controlled trial

Abstract Background Night-time parasympathetic activation, diminished effect of long-acting muscarinic antagonists (LAMA) closer to end of the dosing period, and frequent exacerbations in chronic obstructive pulmonary disease (COPD) during night suggests greater benefits of evening administration of...

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Hlavní autoři:	Pradeesh Sivapalan, Valdemar Rømer, Alexander Jordan, Niklas Dyrby Johansen, Manan Pareek, Daniel Modin, Alexander G. Mathioudakis, Jørgen Vestbo, Anna Kubel Vognsen, Josefin Eklöf, John R. Hurst, Tobias Wirenfeldt Klausen, Tor Biering-Sørensen, Jens-Ulrik Staehr Jensen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	BMC Pulmonary Medicine
Témata:	COPD Long-acting muscarinic antagonists (LAMA) Randomized controlled trial Circadian variation
On-line přístup:	https://doi.org/10.1186/s12890-025-03952-y
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