Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex
The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex an...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Taylor & Francis Group
2017-11-01
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| Серія: | Molecular & Cellular Oncology |
| Предмети: | |
| Онлайн доступ: | http://dx.doi.org/10.1080/23723556.2017.1367873 |
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