The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Abstract Disturbed blood flow and the resulting oscillatory low shear stress (OSS) are key contributors to vascular endothelial dysfunction and the initiation of atherosclerosis. However, the molecular mediators that translate abnormal hemodynamic signals into pathological vascular endothelial respo...

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Detalhes bibliográficos

Principais autores:	Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-09-01
coleção:	Advanced Science
Assuntos:	activator protein 1 atherosclerosis G protein‐coupled receptor kinase 2 shear stress vascular endothelial dysfunction
Acesso em linha:	https://doi.org/10.1002/advs.202501981
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