Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

Abstract Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short term (25 hours) simulated microgravity, we characterize altered genes and pathways at...

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Bibliografische Detailangaben

Hauptverfasser:	Fei Wu, Huixun Du, Eliah Overbey, JangKeun Kim, Priya Makhijani, Nicolas Martin, Chad A. Lerner, Khiem Nguyen, Jordan Baechle, Taylor R. Valentino, Matias Fuentealba, Juliet M. Bartleson, Heather Halaweh, Shawn Winer, Cem Meydan, Francine Garrett-Bakelman, Nazish Sayed, Simon Melov, Masafumi Muratani, Akos A. Gerencser, Herbert G. Kasler, Afshin Beheshti, Christopher E. Mason, David Furman, Daniel A. Winer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-06-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-023-42013-y
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