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New insights on neurodegeneration triggered by iron accumulation: Intersections with neutral lipid metabolism, ferroptosis, and motor impairment

Brain iron accumulation constitutes a pathognomonic indicator in several neurodegenerative disorders. Metal accumulation associated with dopaminergic neuronal death has been documented in Parkinson's disease. Through the use of in vivo and in vitro models, we demonstrated that lipid dysregulation ma...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Athina Maniscalchi, Oriana N. Benzi Juncos, Melisa A. Conde, Melania I. Funk, María E. Fermento, María M. Facchinetti, Alejandro C. Curino, Romina M. Uranga, Natalia P. Alza, Gabriela A. Salvador
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-05-01
Schriftenreihe:Redox Biology
Schlagworte:
Iron accumulation
Midbrain neurodegeneration
Lipid cacostasis
Cholesterol accumulation
Ferroptosis
Movement disorders
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2213231724000508
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