Epigenome-wide profiling of trisomy 18 specific DNA methylation signatures in first-trimester chorionic villi

Abstract Background Trisomy 18 (T18, Edwards syndrome) is a lethal chromosomal disorder characterized by multiple congenital anomalies and high perinatal mortality. Although epigenetic alterations have been described in aneuploidy conditions, their causal role in the pathogenesis of T18 remains uncl...

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Principais autores:	Ju Yeon Kim, Su Ji Yang, Jin Woo Kim, Yong Jun Choi, Hyun Jung Lee, Young Ran Kim, Sang Hee Jung, Ji Hyon Jang, Nari Kim, You Jung Han, Ji Hyae Lim, Hyun Mee Ryu
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-11-01
Series:	Clinical Epigenetics
Assuntos:	Trisomy 18 syndrome DNA methylation Chorionic villi Methyl-capture sequencing
Acceso en liña:	https://doi.org/10.1186/s13148-025-02018-4
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