GIPR:GCGR co-agonism restores normal weight in obese rodents

Objectives: Functional co- and tri-agonists at the receptors for GLP-1, GIP and glucagon effectively decrease body weight and hyperglycemia but are associated with adverse gastrointestinal effects related to GLP-1R agonism. Here we report the discovery that obesity can be reversed in the absence of...

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Huvudupphov:	Diego Perez-Tilve, Fa Zhang, Yujin Zhang, Kaitlyn Lohman, Joyce Sorrell, Andrew Vick, Timo D. Müller, Matthias H. Tschöp, Richard D. DiMarchi
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2026-06-01
Serie:	Molecular Metabolism
Ämnen:	Obesity Type 2 diabetes GIP Glucagon GLP-1 free GIPR:GCGR co-agonism
Länkar:	http://www.sciencedirect.com/science/article/pii/S2212877826000499
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