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Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity

Cancer is a multifactorial disease that may be tackled by targeting different signaling pathways. Heme oxygenase-1 (HO-1) and sigma receptors (σRs) are both overexpressed in different human cancers, including prostate and brain, contributing to the cancer spreading. In the present study, we investig...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Giuseppe Romeo, Valeria Ciaffaglione, Emanuele Amata, Maria Dichiara, Loredana Calabrese, Luca Vanella, Valeria Sorrenti, Salvo Grosso, Agata Grazia D’Amico, Velia D’Agata, Sebastiano Intagliata, Loredana Salerno
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-06-01
Schriftenreihe:Molecules
Schlagworte:
heme oxygenase
HO-1 inhibitors
sigma receptors
σR ligands
DU145
anticancer activity
Online-Zugang:https://www.mdpi.com/1420-3049/26/13/3860
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