Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo

Abstract High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium. Therapeutic intervention occurs at advanced metastatic disease, due to challenges in earl...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Madison Pereira, Alice Glogova, Jacob Haagsma, Julia Stewart, Trevor G. Shepherd, Jim Petrik
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2023-11-01
Sarja:	Journal of Ovarian Research
Aiheet:	Ovarian cancer p53 Mevalonate pathway Fallopian tube orthotopic model Simvastatin
Linkit:	https://doi.org/10.1186/s13048-023-01307-x
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