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Rapid nuclear deadenylation of mammalian messenger RNA

Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm. Here, we combined long-read sequencing with metabolic labeling, s...

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Principais autores: Jonathan Alles, Ivano Legnini, Maddalena Pacelli, Nikolaus Rajewsky
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2023-01-01
Serija:iScience
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Online dostop:http://www.sciencedirect.com/science/article/pii/S2589004222021514
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