Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.

Dengue virus (DENV) is a public health challenge across the tropics and subtropics. Currently, there is no licensed prophylactic or antiviral treatment for dengue. The novel DENV inhibitor JNJ-1802 can significantly reduce viral load in mice and non-human primates. Here, using a mechanistic viral ki...

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Autors principals:	Clare P McCormack, Olivia Goethals, Nele Goeyvaerts, Xavier D Woot de Trixhe, Peggy Geluykens, Doortje Borrenberghs, Neil M Ferguson, Oliver Ackaert, Ilaria Dorigatti
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2023-12-01
Col·lecció:	PLoS Computational Biology
Accés en línia:	https://doi.org/10.1371/journal.pcbi.1011662
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