Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer

Abstract Purpose Radiation therapy has revolutionized the treatment of primary or liver metastases in colorectal cancer (CRC). In colorectal cancer, conventional fractionation (1.8 ~ 2.0 Gy daily) is typically used for treatment. Nevertheless, there is a paucity of research investigating the potenti...

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Detalhes bibliográficos

Principais autores:	Shuxuan Wang, Yanyan Lin, Qianqian Zhao, Huanliang Chen, Shisuo Du, Zhaochong Zeng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	Molecular Medicine
Assuntos:	Irradiation 5-FU Histocompatibility minor 13 Metformin Folate metabolism
Acesso em linha:	https://doi.org/10.1186/s10020-025-01206-5
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