HER2 amplification by next-generation sequencing to identify HER2-positive invasive breast cancer with negative HER2 immunohistochemistry

Abstract Background Human epidermal growth factor receptor 2 (HER2) positive breast carcinomas due to HER2 amplification are associated with aggressive behavior and a poor prognosis. Anti-HER2-targeted therapies are widely used to treat HER2-positive breast carcinomas with excellent outcomes. Accura...

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Principais autores:	Laura Morsberger, Aparna Pallavajjala, Patty Long, Melanie Hardy, Rebecca Park, Rebecca Parish, Azin Nozari, Ying S. Zou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-11-01
coleção:	Cancer Cell International
Assuntos:	Breast cancer Fluorescence in situ hybridization HER2 amplification HER2 immunohistochemistry HER2-positive breast carcinoma Next-generation sequencing
Acesso em linha:	https://doi.org/10.1186/s12935-022-02761-1
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