Limitations of mouse models for sickle cell disease conferred by their human globin transgene configurations
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged, fragmented copies of three human transgenes (HBA1,...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The Company of Biologists
2022-06-01
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| Seria: | Disease Models & Mechanisms |
| Hasła przedmiotowe: | |
| Dostęp online: | http://dmm.biologists.org/content/15/6/dmm049463 |
| Etykiety: |
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