Analysis of mitochondrial DNA heteroplasmy in sporadic ALS suggests technical limitations rather than disease association

Mitochondrial DNA (mtDNA) has received increasing attention in amyotrophic lateral sclerosis (ALS) following the recent report of recurrent low-heteroplasmy mtDNA variants in patients. Here, we performed mtDNA analysis on an independent cohort of 20 sporadic ALS patients using an in-house next-gener...

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Principais autores:	Philippe Codron, Valérie Desquiret, Delphine Prunier, Patrizia Amati-Bonneau, Viviane Nguefackngoune, Clara Rapenne, Louis Legoff, Julien Cassereau, Vincent Procaccio
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2026-06-01
Serija:	Neurobiology of Disease
Teme:	Amyotrophic lateral sclerosis Mitochondria Mitochondrial DNA
Online dostop:	http://www.sciencedirect.com/science/article/pii/S0969996126001579
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