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Hyperoxia Provokes Time- and Dose-Dependent Gut Injury and Endotoxemia and Alters Gut Microbiome and Transcriptome in Mice

Background: Oxygen therapy usually exposes patients to hyperoxia, which induces injuries in the lung, the heart, and the brain. The gut and its microbiome play key roles in critical illnesses, but the impact of hyperoxia on the gut and its microbiome remains not very clear. We clarified the time- an...

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Uloženo v:
Hlavní autoři: Yunhang Li, Yuanfa Tao, Jingyu Xu, Yihuai He, Wen Zhang, Zhigang Jiang, Ying He, Houmei Liu, Miao Chen, Wei Zhang, Zhouxiong Xing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-11-01
Edice:Frontiers in Medicine
Témata:
oxygen therapy
hyperoxia
gut injury
gut microbiome
Enterobacteriaceae
toll-like receptor-4
On-line přístup:https://www.frontiersin.org/articles/10.3389/fmed.2021.732039/full
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