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SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production

Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo evidence of SARS-CoV-2 affecting the vascular endothe...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Veronica Bordoni, Davide Mariotti, Giulia Matusali, Francesca Colavita, Eleonora Cimini, Giuseppe Ippolito, Chiara Agrati
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-09-01
Schriftenreihe:Cells
Schlagworte:
COVID-19
endothelial cells
airway epithelium
senescence
IFN-β
Online-Zugang:https://www.mdpi.com/2073-4409/11/18/2912
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