Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2

Abstract The COVID-19 pandemic, caused by SARS-CoV-2, has underscored the urgency of understanding viral entry mechanisms to develop effective therapeutic strategies. SARS-CoV-2 primarily exploits angiotensin-converting enzyme 2 (ACE2) as its entry receptor and relies on the serine protease TMPRSS2...

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Autori principali:	Martha Rea-Moreno, Lu Tian, Tara N. Tavakol, Min-Chi Yang, Nicole M. Pek, Shubham Gulati, Helena Bugacov, Cristina Cusmai, Gbalekan Dawodu, Remi V. Klotz, Irving M. Garcia, Hsu-Yu Chen, Chennan C. Zhang, Heng Pan, Xisheng Li, Andrea S. Wolf, Huachao Huang, Diana H. Yu, Justin K. Ichida, Susmita Sahoo, Paula M. Cannon, Jianwen Que, Scott A. Scheinin, Daniel Laskey, Alfin G. Vicencio, Megan N. Januska, Brandon A. Guenthart, Jeffrey Johnson, Min Yu, Mingxia Gu, Caterina Tiozzo, Ya-Wen Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-04-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-71680-w
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