Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

Telomeres are important for maintaining genomic stability. Telomere length has been associated with aging, disease, and mortality and is highly heritable (∼82%). In this study, we aimed to identify rare genetic variants associated with telomere length using whole-exome sequence data. We studied 1,30...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ashley van der Spek, Sophie C. Warner, Linda Broer, Christopher P. Nelson, Dina Vojinovic, Shahzad Ahmad, Pascal P. Arp, Rutger W. W. Brouwer, Matthew Denniff, Mirjam C. G. N. van den Hout, Jeroen G. J. van Rooij, Robert Kraaij, Wilfred F. J. van IJcken, Nilesh J. Samani, M. Arfan Ikram, André G. Uitterlinden, Veryan Codd, Najaf Amin, Cornelia M. van Duijn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-04-01
Colecção:	Frontiers in Genetics
Assuntos:	telomere aging whole exome sequencing meta-analysis ATM RPL8
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fgene.2020.00337/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!