Spirobarbiturates with a pyrrolizidine moiety: synthesis, structure and biological evaluation

Polycyclic spirobarbiturates containing a pyrrolizidine moiety were synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of alloxan, ʟ-proline and N-substituted maleimides. The reaction stereoselectivity was found to depend on the nature of substituents in the maleimide: in m...

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Hlavní autoři:	Arthur A. Puzyrkov, Andrew S. Drachuk, Ekaterina A. Popova, Alexander V. Stepakov, Vitali M. Boitsov
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Beilstein-Institut 2026-02-01
Edice:	Beilstein Journal of Organic Chemistry
Témata:	alloxan antiproliferative activity azomethine ylides 1,3-dipolar cycloaddition maleimides pyrrolizidine moiety spirobarbiturates three-component reactions
On-line přístup:	https://doi.org/10.3762/bjoc.22.20
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