Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Autophagic activity declines with age in several tissues and is linked to aging-associated functional decline and pathologies. Here the authors show that Rubicon, a negative regulator of autophagy, decreases in adipocytes with age, and its loss leads to adipocyte dysfunction via excess autophagic de...

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Autors principals:	Tadashi Yamamuro, Tsuyoshi Kawabata, Atsunori Fukuhara, Shotaro Saita, Shuhei Nakamura, Hikari Takeshita, Mari Fujiwara, Yusuke Enokidani, Gota Yoshida, Keisuke Tabata, Maho Hamasaki, Akiko Kuma, Koichi Yamamoto, Iichiro Shimomura, Tamotsu Yoshimori
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2020-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-020-17985-w
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