Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics

The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various antimicrobials. The ncAA Nε-Boc-L-lysine (Boc...

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Hauptverfasser:	Maike Bartholomae, Tobias Baumann, Jessica H. Nickling, David Peterhoff, Ralf Wagner, Nediljko Budisa, Oscar P. Kuipers
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2018-04-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	stop codon suppression pyrrolysyl-tRNA synthetase nisin orthogonal translation system antimicrobial peptides bacteriocin
Online-Zugang:	http://journal.frontiersin.org/article/10.3389/fmicb.2018.00657/full
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