Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach

Abstract Background Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are synthetic chemicals known for their widespread use and environmental persistence. These compounds have been increasingly linked to hepatotoxicity and t...

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Detalhes bibliográficos

Principais autores:	Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	Journal of Translational Medicine
Assuntos:	PFAS Network toxicology Hepatocellular carcinoma Machine learning Single-cell sequencing Molecular docking
Acesso em linha:	https://doi.org/10.1186/s12967-025-06517-z
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