Islet function impairment outcomes of immune checkpoint inhibitors in cancer patients: a systematic review and meta-analysis

BackgroundImmune checkpoint inhibitors (ICPis) are associated with islet function impairment (IFI), manifesting as hyperglycemia, diabetes mellitus (DM), or diabetic ketoacidosis (DKA). Delayed detection and management may lead to irreversible β-cell damage and life-threatening complications. We con...

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Detalhes bibliográficos

Principais autores:	Qi Hu, Yongzheng Fan, Ping He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
Colecção:	Frontiers in Immunology
Assuntos:	CTLA-4 inhibitors diabetes mellitus endocrine adverse events immune checkpoint inhibitors PD-1 inhibitors PD-L1 inhibitors
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1669492/full
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