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Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma

Abstract Liquid biopsies and cell-free DNA (cfDNA) offer minimally invasive methods for the diagnosis and monitoring of Ewing Sarcoma (EwS). EwS have a low tumour mutational burden and their detection with plasma cfDNA is challenging. We hypothesised that analysing the cfDNA methylome and fragmentom...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Sophie A Richardson, Aram Safrastyan, Mina Karimpour, Gayatri Gulati, Patrick J B Harker, Alan Redfern, Simon P Pearce, Vsevolod J Makeev, Bernadette Brennan, Alexander T J Lee, Alexandra Clipson, Steven M Hill, Caroline Dive, Dominic G Rothwell, Martin G McCabe, Florent Mouliere
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Springer Nature 2026-03-01
Rangatū:EMBO Molecular Medicine
Ngā marau:
Cell-Free DNA
Ewing Sarcoma
Fragmentomics
Liquid Biopsy
Methylome
Urunga tuihono:https://doi.org/10.1038/s44321-026-00396-7
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