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Pan-cancer integrative analysis of whole-genome De novo somatic point mutations reveals 17 cancer types

Abstract Background The advent of high throughput sequencing has enabled researchers to systematically evaluate the genetic variations in cancer, identifying many cancer-associated genes. Although cancers in the same tissue are widely categorized in the same group, they demonstrate many differences...

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Principais autores: Amin Ghareyazi, Amirreza Kazemi, Kimia Hamidieh, Hamed Dashti, Maedeh Sadat Tahaei, Hamid R. Rabiee, Hamid Alinejad-Rokny, Iman Dehzangi
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2022-07-01
Series:BMC Bioinformatics
Assuntos:
Pan-cancer
Somatic point mutations
Cancer subtyping
Biomarker discovery
Driver genes
Personalized medicine
Acceso en liña:https://doi.org/10.1186/s12859-022-04840-6
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