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Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection.

Viruses, including picornaviruses, modulate cellular metabolism to generate sufficient building blocks for virus replication and dissemination. Previously, we showed that two picornaviruses, coxsackievirus B3 (CVB3) and EMCV, remodel nucleotide metabolism during infection. Here, we investigated whet...

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Principais autores: Lonneke V Nouwen, Esther A Zaal, Inge Buitendijk, Marleen Zwaagstra, Chiara Aloise, Arno L W van Vliet, Jelle G Schipper, Alain van Mil, Celia R Berkers, Frank J M van Kuppeveld
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2025-07-01
Serier:PLoS Pathogens
Online adgang:https://doi.org/10.1371/journal.ppat.1013293
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