Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

Hutchinson-Gilford progeria syndrome (HGPS), a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the <i>LMNA</i> gene. Nearly 90% of HGPS cases carry the G608G mutation within exon 11 that generates a t...

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Hlavní autoři:	Chang Liu, Rouven Arnold, Gonçalo Henriques, Karima Djabali
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-10-01
Edice:	Cells
Témata:	progerin baricitinib senescence jak-stat inflammation age-related disease progeria
On-line přístup:	https://www.mdpi.com/2073-4409/8/10/1276
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